Facts

Prof. Dr. med. Philip Rosenstiel

Phone: +49 (0)431-500-15111
Institute: Institute of Clinical Molecular Biology (IKMB) / Kiel University (CAU), University Medical Center Schleswig-Holstein (UKSH)
Address: Rosalind-Franklin-Str. 12, 24105 Kiel, Germany
Group: Systems Immunology
Platforms: Competence Center for Genomic Analysis Kiel (CCGA)

Philip Rosenstiel is principle investigator of project 3. He holds a W3-professorship at Kiel University and is one of three directors of the Institute of Clinical Molecular Biology.

Special fields:

  • Molecular Systems / Translational Medicine
  • Epigenetics, Microbiome
  • Mucosal immunology

Project-related publications

Endoplasmic reticulum stress in the intestinal epithelium initiates purine metabolite synthesis and promotes Th17 cell differentiation in the gut.

Jinzhi Duan, Juan D Matute, Lukas W Unger, Thomas Hanley, Alexandra Schnell, Xi Lin, Niklas Krupka, Paul Griebel, Conner Lambden, Brandon Sit, Joep Grootjans, Michal Pyzik, Felix Sommer, Sina Kaiser, Maren Falk-Paulsen, Helmut Grasberger, John Y Kao, Tobias Fuhrer, Hai Li, Donggi Paik, Yunjin Lee, Samuel Refetoff, Jonathan N Glickman, Adrienne W Paton, Lynn Bry, James C Paton, Uwe Sauer, Andrew J Macpherson, Philip Rosenstiel, Vijay K Kuchroo, Matthew K Waldor, Jun R Huh, Arthur Kaser, Richard S Blumberg

Immunity (Cambridge, Mass.)
2023

A gut bacterial signature in blood and liver tissue characterizes cirrhosis and hepatocellular carcinoma.

Maria Effenberger, Silvio Waschina, Christina Bronowski, Gregor Sturm, Oronzo Tassiello, Felix Sommer, Andreas Zollner, Christina Watschinger, Felix Grabherr, Ronald Gstir, Christoph Grander, Barbara Enrich, Reto Bale, Daniel Putzer, Angela Djanani, Alexander R Moschen, Heinz Zoller, Jan Rupp, Stefan Schreiber, Remy Burcelin, Cornelia Lass-Flörl, Zlatko Trajanoski, Georg Oberhuber, Philip Rosenstiel, Timon E Adolph, Konrad Aden, Herbert Tilg

Hepatology communications
2023

PUFA-induced metabolic enteritis as a fuel for Crohn’s disease.

Julian Schwärzler, Lisa Mayr, Arnau Vich Vila, Felix Grabherr, Lukas Niederreiter, Maureen Philipp, Christoph Grander, Moritz Meyer, Almina Jukic, Simone Tröger, Barbara Enrich, Nicole Przysiecki, Markus Tschurtschenthaler, Felix Sommer, Irmgard Kronberger, Jakob Koch, Richard Hilbe, Michael W Hess, Georg Oberhuber, Susanne Sprung, Qitao Ran, Robert Koch, Maria Effenberger, Nicole C Kaneider, Verena Wieser, Markus A Keller, Rinse K Weersma, Konrad Aden, Philip Rosenstiel, Richard S Blumberg, Arthur Kaser, Herbert Tilg, Timon E Adolph

Gastroenterology (New York, N.Y. 1943)
2022

DNA methyltransferase 3A controls intestinal epithelial barrier function and regeneration in the colon.

Antonella Fazio, Dora Bordoni, Jan W P Kuiper, Saskia Weber-Stiehl, Stephanie T Stengel, Philipp Arnold, David Ellinghaus, Go Ito, Florian Tran, Berith Messner, Anna Henning, Joana P Bernardes, Robert Häsler, Anne Luzius, Simon Imm, Finn Hinrichsen, Andre Franke, Samuel Huber, Susanna Nikolaus, Konrad Aden, Stefan Schreiber, Felix Sommer, Gioacchino Natoli, Neha Mishra, Philip Rosenstiel

Nature communications
2022

Bacterial sensing via neuronal Nod2 regulates appetite and body temperature.

Ilana Gabanyi, Gabriel Lepousez, Richard Wheeler, Alba Vieites-Prado, Antoine Nissant, Sébastien Wagner, Carine Moigneu, Sophie Dulauroy, Samia Hicham, Bernadette Polomack, Florine Verny, Philip Rosenstiel, Nicolas Renier, Ivo Gomperts Boneca, Gérard Eberl, Pierre-Marie Lledo

Science : a weekly journal devoted to the advancement of science / American Association for the Advancement of Science
2022

Inflammatory type 2 conventional dendritic cells contribute to murine and human cholangitis.

Anna-Lena Müller, Christian Casar, Max Preti, Daria Krzikalla, Cornelia Gottwick, Pia Averhoff, Philip Rosenstiel, Mathias Gelderblom, Marcus Altfeld, Ansgar W Lohse, Silja Steinmann, Marcial Sebode, Jenny Krause, Dorothee Schwinge, Christoph Schramm, Antonella Carambia, Johannes Herkel

Journal of hepatology : the journal of the European Association for the Study of the Liver
2022

Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis.

Finn Hinrichsen, Jacob Hamm, Magdalena Westermann, Lena Schröder, Kensuke Shima, Neha Mishra, Alesia Walker, Nina Sommer, Kenneth Klischies, Daniela Prasse, Johannes Zimmermann, Sina Kaiser, Dora Bordoni, Antonella Fazio, Georgios Marinos, Georg Laue, Simon Imm, Valentina Tremaroli, Marijana Basic, Robert Häsler, Ruth A Schmitz, Stefan Krautwald, Andrea Wolf, Bärbel Stecher, Philippe Schmitt-Kopplin, Christoph Kaleta, Jan Rupp, Fredrik Bäckhed, Philip Rosenstiel, Felix Sommer

Cell metabolism
2021

Dietary lipids fuel GPX4-restricted enteritis resembling Crohn’s disease.

Lisa Mayr, Felix Grabherr, Julian Schwärzler, Isabelle Reitmeier, Felix Sommer, Thomas Gehmacher, Lukas Niederreiter, Gui-Wei He, Barbara Ruder, Kai T R Kunz, Piotr Tymoszuk, Richard Hilbe, David Haschka, Clemens Feistritzer, Romana R Gerner, Barbara Enrich, Nicole Przysiecki, Markus Seifert, Markus A Keller, Georg Oberhuber, Susanne Sprung, Qitao Ran, Robert Koch, Maria Effenberger, Ivan Tancevski, Heinz Zoller, Alexander R Moschen, Günter Weiss, Christoph Becker, Philip Rosenstiel, Arthur Kaser, Herbert Tilg, Timon E Adolph

Nature communications
2020

Low-Avidity CD4+ T Cell Responses to SARS-CoV-2 in Unexposed Individuals and Humans with Severe COVID-19.

Petra Bacher, Elisa Rosati, Daniela Esser, Gabriela Rios Martini, Carina Saggau, Esther Schiminsky, Justina Dargvainiene, Ina Schröder, Imke Wieters, Yascha Khodamoradi, Fabian Eberhardt, Maria J G T Vehreschild, Holger Neb, Michael Sonntagbauer, Claudio Conrad, Florian Tran, Philip Rosenstiel, Robert Markewitz, Klaus-Peter Wandinger, Max Augustin, Jan Rybniker, Matthias Kochanek, Frank Leypoldt, Oliver A Cornely, Philipp Koehler, Andre Franke, Alexander Scheffold

Immunity (Cambridge, Mass.)
2020

Metabolic Functions of Gut Microbes Associate With Efficacy of Tumor Necrosis Factor Antagonists in Patients with Inflammatory Bowel Diseases.

Konrad Aden, Ateequr Rehman, Silvio Waschina, Wei-Hung Pan, Alesia Walker, Marianna Lucio, Alejandro Mena Nunez, Richa Bharti, Johannes Zimmerman, Johannes Bethge, Berenice Schulte, Dominik Schulte, Andre Franke, Susanna Nikolaus, Johann Oltmann Schroeder, Doris Vandeputte, Jeroen Raes, Silke Szymczak, Georg H Waetzig, Rainald Zeuner, Philippe Schmitt-Kopplin, Christoph Kaleta, Stefan Schreiber, Philip Rosenstiel

Gastroenterology (New York, N.Y. 1943)
2019

Protein-coding variants contribute to the risk of atopic dermatitis and skin-specific gene expression.

Sören Mucha, Hansjörg Baurecht, Natalija Novak, Elke Rodríguez, Saptarshi Bej, Gabriele Mayr, Hila Emmert, Dora Stölzl, Sascha Gerdes, Frauke Degenhardt, Matthias Hübenthal, Eva Ellinghaus, Eun Suk Jung, Jan Christian Kässens, Lars Wienbrandt, Wolfgang Lieb, Martina Müller-Nurasyid, Melanie Hotze, Nick Dand, Sarah Grosche, Ingo Marenholz, Andreas Arnold, Georg Homuth, Carsten O Schmidt, Ulrike Wehkamp, Markus M Nöthen, Per Hoffmann, Lavinia Paternoster, Marie Standl, Klaus Bønnelykke, Tarunveer S Ahluwalia, Hans Bisgaard, Annette Peters, Christian Gieger, Melanie Waldenberger, Holger Schulz, Konstantin Strauch, Thomas Werfel, Young-Ae Lee, Markus Wolfien, Philip Rosenstiel, Olaf Wolkenhauer, Stefan Schreiber, Andre Franke, Stephan Weidinger, David Ellinghaus

Journal of allergy and clinical immunology
2019

ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING.

Konrad Aden, Florian Tran, Go Ito, Raheleh Sheibani-Tezerji, Simone Lipinski, Jan W Kuiper, Markus Tschurtschenthaler, Svetlana Saveljeva, Joya Bhattacharyya, Robert Häsler, Kareen Bartsch, Anne Luzius, Marlene Jentzsch, Maren Falk-Paulsen, Stephanie T Stengel, Lina Welz, Robin Schwarzer, Björn Rabe, Winfried Barchet, Stefan Krautwald, Gunther Hartmann, Manolis Pasparakis, Richard S Blumberg, Stefan Schreiber, Arthur Kaser, Philip Rosenstiel

The journal of experimental medicine
2018

Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota.

Jun Wang, Louise B Thingholm, Jurgita Skiecevičienė, Philipp Rausch, Martin Kummen, Johannes R Hov, Frauke Degenhardt, Femke-Anouska Heinsen, Malte C Rühlemann, Silke Szymczak, Kristian Holm, Tönu Esko, Jun Sun, Mihaela Pricop-Jeckstadt, Samer Al-Dury, Pavol Bohov, Jörn Bethune, Felix Sommer, David Ellinghaus, Rolf K Berge, Matthias Hübenthal, Manja Koch, Karin Schwarz, Gerald Rimbach, Patricia Hübbe, Wei-Hung Pan, Raheleh Sheibani-Tezerji, Robert Häsler, Philipp Rosenstiel, Mauro D’Amato, Katja Cloppenborg-Schmidt, Sven Künzel, Matthias Laudes, Hanns-Ulrich Marschall, Wolfgang Lieb, Ute Nöthlings, Tom H Karlsen, John F Baines, Andre Franke

Nature genetics
2016

Participating Institutes