Facts

Prof. Dr. rer. nat. Andre Franke

Phone: +49 (0)431 - 500 - 15 112
Institute: Institute of Clinical Molecular Biology (IKMB) / Kiel University (CAU), University Medical Center Schleswig-Holstein (UKSH)
Address: Rosalind-Franklin-Str. 12, 24105 Kiel, Germany
Group: Genetics and Bioinformatics
Platforms: Competence Center for Genomic Analysis Kiel (CCGA)

Andre Franke is the speaker of the RU 5042 miTarget and principle investigator of project 1. He holds a W3- professorship at Kiel University and is one of three directors of the Institute of Clinical Molecular Biology. He leads the Genetics and Bioinformatics Subgroup of the institute and is responsible for the high-throughput facilities (including the data analysis and management teams) in the Centre for Molecular Biosciences (ZMB). He also serves as the speaker of the DFG Research Training Group 1743 Genes, Environment and Inflammation.

Special fields:

  • Molecular genetics
  • Immunogenetics
  • Bioinformatics
  • Next-generation sequencing
  • Technology development

Project-related publications

P1

Autoantigen-specific CD4<sup>+</sup> T cells acquire an exhausted phenotype and persist in human antigen-specific autoimmune diseases.

Carina Saggau, Petra Bacher, Daniela Esser, Mahdi Rasa, Silja Meise, Nicola Mohr, Nora Kohlstedt, Andreas Hutloff, Sarah-Sophie Schacht, Justina Dargvainiene, Gabriela Rios Martini, Klarissa H Stürner, Ina Schröder, Robert Markewitz, Johannes Hartl, Maria Hastermann, Ankelien Duchow, Patrick Schindler, Mareike Becker, Carolin Bautista, Judith Gottfreund, Jörn Walter, Julia K Polansky, Mingxing Yang, Reza Naghavian, Mareike Wendorff, Ev-Marie Schuster, Andreas Dahl, Andreas Petzold, Susanne Reinhardt, Andre Franke, Marek Wieczorek, Lea Henschel, Daniel Berger, Guido Heine, Maike Holtsche, Vivien Häußler, Christian Peters, Enno Schmidt, Simon Fillatreau, Dirk H Busch, Klaus-Peter Wandinger, Kilian Schober, Roland Martin, Friedemann Paul, Frank Leypoldt, Alexander Scheffold

Immunity (Cambridge, Mass.)
2024
P1

Selection of cross-reactive T cells by commensal and food-derived yeasts drives cytotoxic TH1 cell responses in Crohn’s disease.

Gabriela Rios Martini, Ekaterina Tikhonova, Elisa Rosati, Meghan Bialt DeCelie, Laura Katharina Sievers, Florian Tran, Matthias Lessing, Arne Bergfeld, Sophia Hinz, Susanna Nikolaus, Julia Kümpers, Anna Matysiak, Philipp Hofmann, Carina Saggau, Stephan Schneiders, Ann-Kristin Kamps, Gunnar Jacobs, Wolfgang Lieb, Jochen Maul, Britta Siegmund, Barbara Seegers, Holger Hinrichsen, Hans-Heinrich Oberg, Daniela Wesch, Stefan Bereswill, Markus M Heimesaat, Jan Rupp, Olaf Kniemeyer, Axel A Brakhage, Sascha Brunke, Bernhard Hube, Konrad Aden, Andre Franke, Iliyan D Iliev, Alexander Scheffold, Stefan Schreiber, Petra Bacher

Nature medicine
2023
P1

Targeted suppression of human IBD-associated gut microbiota commensals by phage consortia for treatment of intestinal inflammation.

Sara Federici, Sharon Kredo-Russo, Rafael Valdés-Mas, Denise Kviatcovsky, Eyal Weinstock, Yulia Matiuhin, Yael Silberberg, Koji Atarashi, Munehiro Furuichi, Akihiko Oka, Bo Liu, Morine Fibelman, Iddo Nadav Weiner, Efrat Khabra, Nyssa Cullin, Noa Ben-Yishai, Dana Inbar, Hava Ben-David, Julian Nicenboim, Noga Kowalsman, Wolfgang Lieb, Edith Kario, Tal Cohen, Yael Friedman Geffen, Lior Zelcbuch, Ariel Cohen, Urania Rappo, Inbar Gahali-Sass, Myriam Golembo, Vered Lev, Mally Dori-Bachash, Hagit Shapiro, Claudia Moresi, Amanda Cuevas-Sierra, Gayatree Mohapatra, Lara Kern, Danping Zheng, Samuel Philip Nobs, Jotham Suez, Noa Stettner, Alon Harmelin, Naomi Zak, Sailaja Puttagunta, Merav Bassan, Kenya Honda, Harry Sokol, Corinna Bang, Andre Franke, Christoph Schramm, Nitsan Maharshak, Ryan Balfour Sartor, Rotem Sorek, Eran Elinav

P1

A novel unconventional T cell population enriched in Crohn’s disease.

Elisa Rosati, Gabriela Rios Martini, Mikhail V Pogorelyy, Anastasia A Minervina, Frauke Degenhardt, Mareike Wendorff, Soner Sari, Gabriele Mayr, Antonella Fazio, Christel Marie Dowds, Charlotte Hauser, Florian Tran, Witigo von Schönfels, Julius Pochhammer, Maria A Salnikova, Charlot Jaeckel, Johannes Boy Gigla, Sanaz Sedghpour Sabet, Matthias Hübenthal, Esther Schiminsky, Stefan Schreiber, Philip C Rosenstiel, Alexander Scheffold, Paul G Thomas, Wolfgang Lieb, Bernd Bokemeyer, Maria Witte, Konrad Aden, Alexander Hendricks, Clemens Schafmayer, Jan-Hendrick Egberts, Ilgar Z Mamedov, Petra Bacher, Andre Franke

Gut : journal of the British Society of Gastroenterology
2022
P1

Detailed transcriptional landscape of peripheral blood points to increased neutrophil activation in treatment-naïve inflammatory bowel disease.

Simonas Juzenas, Matthias Hübenthal, Carl Mårten Lindqvist, Robert Kruse, Tim Alexander Steiert, Frauke Degenhardt, Dominik Schulte, Susanna Nikolaus, Sebastian Zeissig, Daniel Bergemalm, Sven Almer, Henrik Hjortswang, Francesca Bresso, Nina Strüning, Juozas Kupcinskas, Andreas Keller, Wolfgang Lieb, Philip Rosenstiel, Stefan Schreiber, Mauro D’Amato, Jonas Halfvarson, Georg Hemmrich-Stanisak, Andre Franke

Journal of Crohn's & colitis : international journal devoted to inflammatory bowel diseases
2022

Host genetic factors related to innate immunity, environmental sensing and cellular functions are associated with human skin microbiota.

Lucas Moitinho-Silva, Frauke Degenhardt, Elke Rodriguez, Hila Emmert, Simonas Juzenas, Lena Möbus, Florian Uellendahl-Werth, Nicole Sander, Hansjörg Baurecht, Lukas Tittmann, Wolfgang Lieb, Christian Gieger, Annette Peters, David Ellinghaus, Corinna Bang, Andre Franke, Stephan Weidinger, Malte Christoph Rühlemann

Nature communications
2022
P5

DNA methyltransferase 3A controls intestinal epithelial barrier function and regeneration in the colon.

Antonella Fazio, Dora Bordoni, Jan W P Kuiper, Saskia Weber-Stiehl, Stephanie T Stengel, Philipp Arnold, David Ellinghaus, Go Ito, Florian Tran, Berith Messner, Anna Henning, Joana P Bernardes, Robert Häsler, Anne Luzius, Simon Imm, Finn Hinrichsen, Andre Franke, Samuel Huber, Susanna Nikolaus, Konrad Aden, Stefan Schreiber, Felix Sommer, Gioacchino Natoli, Neha Mishra, Philip Rosenstiel

Nature communications
2022
P1

Reporting guidelines for human microbiome research: the STORMS checklist.

Chloe Mirzayi, Audrey Renson, Fatima Zohra, Shaimaa Elsafoury, Ludwig Geistlinger, Lora J Kasselman, Kelly Eckenrode, Janneke van de Wijgert, Amy Loughman, Francine Z Marques, David A MacIntyre, Manimozhiyan Arumugam, Rimsha Azhar, Francesco Beghini, Kirk Bergstrom, Ami Bhatt, Jordan E Bisanz, Jonathan Braun, Hector Corrada Bravo, Gregory A Buck, Frederic Bushman, David Casero, Gerard Clarke, Maria Carmen Collado, Paul D Cotter, John F Cryan, Ryan T Demmer, Suzanne Devkota, Eran Elinav, Juan S Escobar, Jennifer Fettweis, Robert D Finn, Anthony A Fodor, Sofia Forslund, Andre Franke, Cesare Furlanello, Jack Gilbert, Elizabeth Grice, Benjamin Haibe-Kains, Scott Handley, Pamela Herd, Susan Holmes, Jonathan P Jacobs, Lisa Karstens, Rob Knight, Dan Knights, Omry Koren, Douglas S Kwon, Morgan Langille, Brianna Lindsay, Dermot McGovern, Alice C McHardy, Shannon McWeeney, Noel T Mueller, Luigi Nezi, Matthew Olm, Noah Palm, Edoardo Pasolli, Jeroen Raes, Matthew R Redinbo, Malte Rühlemann, R Balfour Sartor, Patrick D Schloss, Lynn Schriml, Eran Segal, Michelle Shardell, Thomas Sharpton, Ekaterina Smirnova, Harry Sokol, Justin L Sonnenburg, Sujatha Srinivasan, Louise B Thingholm, Peter J Turnbaugh, Vaibhav Upadhyay, Ramona L Walls, Paul Wilmes, Takuji Yamada, Georg Zeller, Mingyu Zhang, Ni Zhao, Liping Zhao, Wenjun Bao, Aedin Culhane, Viswanath Devanarayan, Joaquin Dopazo, Xiaohui Fan, Matthias Fischer, Wendell Jones, Rebecca Kusko, Christopher E Mason, Tim R Mercer, Susanna-Assunta Sansone, Andreas Scherer, Leming Shi, Shraddha Thakkar, Weida Tong, Russ Wolfinger, Christopher Hunter, Nicola Segata, Curtis Huttenhower, Jennifer B Dowd, Heidi E Jones, Levi Waldron

Nature medicine
2021
P5

Short-term physical exercise impacts on the human holobiont obtained by a randomised intervention study.

Lucas Moitinho-Silva, Michelle Wegener, Sandra May, Florian Schrinner, Awais Akhtar, Teide J Boysen, Eva Schaeffer, Clint Hansen, Timo Schmidt, Malte C Rühlemann, Matthias Hübenthal, Philipp Rausch, Mustafa T Kondakci, Walter Maetzler, Stephan Weidinger, Matthias Laudes, Philip Süß, Dominik Schulte, Ralf Junker, Felix Sommer, Burkhard Weisser, Corinna Bang, Andre Franke

BMC microbiology
2021
P1

Trans-ethnic analysis of the human leukocyte antigen region for ulcerative colitis reveals shared but also ethnicity-specific disease associations.

Frauke Degenhardt, Gabriele Mayr, Mareike Wendorff, Gabrielle Boucher, Eva Ellinghaus, David Ellinghaus, Hesham ElAbd, Elisa Rosati, Matthias Hübenthal, Simonas Juzenas, Shifteh Abedian, Homayon Vahedi, B K Thelma, Suk-Kyun Yang, Byong Duk Ye, Jae Hee Cheon, Lisa Wu Datta, Naser Ebrahim Daryani, Pierre Ellul, Motohiro Esaki, Yuta Fuyuno, Dermot P B McGovern, Talin Haritunians, Myhunghee Hong, Garima Juyal, Eun Suk Jung, Michiaki Kubo, Subra Kugathasan, Tobias L Lenz, Stephen Leslie, Reza Malekzadeh, Vandana Midha, Allan Motyer, Siew C Ng, David T Okou, Soumya Raychaudhuri, John Schembri, Stefan Schreiber, Kyuyoung Song, Ajit Sood, Atsushi Takahashi, Esther A Torres, Junji Umeno, Behrooz Z Alizadeh, Rinse K Weersma, Sunny H Wong, Keiko Yamazaki, Tom H Karlsen, John D Rioux, Steven R Brant, Andre Franke

Human molecular genetics
2021

Low-Avidity CD4+ T Cell Responses to SARS-CoV-2 in Unexposed Individuals and Humans with Severe COVID-19.

Petra Bacher, Elisa Rosati, Daniela Esser, Gabriela Rios Martini, Carina Saggau, Esther Schiminsky, Justina Dargvainiene, Ina Schröder, Imke Wieters, Yascha Khodamoradi, Fabian Eberhardt, Maria J G T Vehreschild, Holger Neb, Michael Sonntagbauer, Claudio Conrad, Florian Tran, Philip Rosenstiel, Robert Markewitz, Klaus-Peter Wandinger, Max Augustin, Jan Rybniker, Matthias Kochanek, Frank Leypoldt, Oliver A Cornely, Philipp Koehler, Andre Franke, Alexander Scheffold

Immunity (Cambridge, Mass.)
2020

Genomewide Association Study of Severe Covid-19 with Respiratory Failure.

David Ellinghaus, Frauke Degenhardt, Luis Bujanda, Maria Buti, Agustín Albillos, Pietro Invernizzi, Javier Fernández, Daniele Prati, Guido Baselli, Rosanna Asselta, Marit M Grimsrud, Chiara Milani, Fátima Aziz, Jan Kässens, Sandra May, Mareike Wendorff, Lars Wienbrandt, Florian Uellendahl-Werth, Tenghao Zheng, Xiaoli Yi, Raúl de Pablo, Adolfo G Chercoles, Adriana Palom, Alba-Estela Garcia-Fernandez, Francisco Rodriguez-Frias, Alberto Zanella, Alessandra Bandera, Alessandro Protti, Alessio Aghemo, Ana Lleo, Andrea Biondi, Andrea Caballero-Garralda, Andrea Gori, Anja Tanck, Anna Carreras Nolla, Anna Latiano, Anna Ludovica Fracanzani, Anna Peschuck, Antonio Julià, Antonio Pesenti, Antonio Voza, David Jiménez, Beatriz Mateos, Beatriz Nafria Jimenez, Carmen Quereda, Cinzia Paccapelo, Christoph Gassner, Claudio Angelini, Cristina Cea, Aurora Solier, David Pestaña, Eduardo Muñiz-Diaz, Elena Sandoval, Elvezia M Paraboschi, Enrique Navas, Félix García Sánchez, Ferruccio Ceriotti, Filippo Martinelli-Boneschi, Flora Peyvandi, Francesco Blasi, Luis Téllez, Albert Blanco-Grau, Georg Hemmrich-Stanisak, Giacomo Grasselli, Giorgio Costantino, Giulia Cardamone, Giuseppe Foti, Serena Aneli, Hayato Kurihara, Hesham ElAbd, Ilaria My, Iván Galván-Femenia, Javier Martín, Jeanette Erdmann, Jose Ferrusquía-Acosta, Koldo Garcia-Etxebarria, Laura Izquierdo-Sanchez, Laura R Bettini, Lauro Sumoy, Leonardo Terranova, Leticia Moreira, Luigi Santoro, Luigia Scudeller, Francisco Mesonero, Luisa Roade, Malte C Rühlemann, Marco Schaefer, Maria Carrabba, Mar Riveiro-Barciela, Maria E Figuera Basso, Maria G Valsecchi, María Hernandez-Tejero, Marialbert Acosta-Herrera, Mariella D’Angiò, Marina Baldini, Marina Cazzaniga, Martin Schulzky, Maurizio Cecconi, Michael Wittig, Michele Ciccarelli, Miguel Rodríguez-Gandía, Monica Bocciolone, Monica Miozzo, Nicola Montano, Nicole Braun, Nicoletta Sacchi, Nilda Martínez, Onur Özer, Orazio Palmieri, Paola Faverio, Paoletta Preatoni, Paolo Bonfanti, Paolo Omodei, Paolo Tentorio, Pedro Castro, Pedro M Rodrigues, Aaron Blandino Ortiz, Rafael de Cid, Ricard Ferrer, Roberta Gualtierotti, Rosa Nieto, Siegfried Goerg, Salvatore Badalamenti, Sara Marsal, Giuseppe Matullo, Serena Pelusi, Simonas Juzenas, Stefano Aliberti, Valter Monzani, Victor Moreno, Tanja Wesse, Tobias L Lenz, Tomas Pumarola, Valeria Rimoldi, Silvano Bosari, Wolfgang Albrecht, Wolfgang Peter, Manuel Romero-Gómez, Mauro D’Amato, Stefano Duga, Jesus M Banales, Johannes R Hov, Trine Folseraas, Luca Valenti, Andre Franke, Tom H Karlsen

New England journal of medicine
2020

Protein-coding variants contribute to the risk of atopic dermatitis and skin-specific gene expression.

Sören Mucha, Hansjörg Baurecht, Natalija Novak, Elke Rodríguez, Saptarshi Bej, Gabriele Mayr, Hila Emmert, Dora Stölzl, Sascha Gerdes, Frauke Degenhardt, Matthias Hübenthal, Eva Ellinghaus, Eun Suk Jung, Jan Christian Kässens, Lars Wienbrandt, Wolfgang Lieb, Martina Müller-Nurasyid, Melanie Hotze, Nick Dand, Sarah Grosche, Ingo Marenholz, Andreas Arnold, Georg Homuth, Carsten O Schmidt, Ulrike Wehkamp, Markus M Nöthen, Per Hoffmann, Lavinia Paternoster, Marie Standl, Klaus Bønnelykke, Tarunveer S Ahluwalia, Hans Bisgaard, Annette Peters, Christian Gieger, Melanie Waldenberger, Holger Schulz, Konstantin Strauch, Thomas Werfel, Young-Ae Lee, Markus Wolfien, Philip Rosenstiel, Olaf Wolkenhauer, Stefan Schreiber, Andre Franke, Stephan Weidinger, David Ellinghaus

Journal of allergy and clinical immunology
2019

Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy.

Rosina Pryor, Povilas Norvaisas, Georgios Marinos, Lena Best, Louise B Thingholm, Leonor M Quintaneiro, Wouter De Haes, Daniela Esser, Silvio Waschina, Celia Lujan, Reuben L Smith, Timothy A Scott, Daniel Martinez-Martinez, Orla Woodward, Kevin Bryson, Matthias Laudes, Wolfgang Lieb, Riekelt H Houtkooper, Andre Franke, Liesbet Temmerman, Ivana Bjedov, Helena M Cochemé, Christoph Kaleta, Filipe Cabreiro

Metabolic Functions of Gut Microbes Associate With Efficacy of Tumor Necrosis Factor Antagonists in Patients with Inflammatory Bowel Diseases.

Konrad Aden, Ateequr Rehman, Silvio Waschina, Wei-Hung Pan, Alesia Walker, Marianna Lucio, Alejandro Mena Nunez, Richa Bharti, Johannes Zimmerman, Johannes Bethge, Berenice Schulte, Dominik Schulte, Andre Franke, Susanna Nikolaus, Johann Oltmann Schroeder, Doris Vandeputte, Jeroen Raes, Silke Szymczak, Georg H Waetzig, Rainald Zeuner, Philippe Schmitt-Kopplin, Christoph Kaleta, Stefan Schreiber, Philip Rosenstiel

Gastroenterology (New York, N.Y. 1943)
2019

Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota.

Jun Wang, Louise B Thingholm, Jurgita Skiecevičienė, Philipp Rausch, Martin Kummen, Johannes R Hov, Frauke Degenhardt, Femke-Anouska Heinsen, Malte C Rühlemann, Silke Szymczak, Kristian Holm, Tönu Esko, Jun Sun, Mihaela Pricop-Jeckstadt, Samer Al-Dury, Pavol Bohov, Jörn Bethune, Felix Sommer, David Ellinghaus, Rolf K Berge, Matthias Hübenthal, Manja Koch, Karin Schwarz, Gerald Rimbach, Patricia Hübbe, Wei-Hung Pan, Raheleh Sheibani-Tezerji, Robert Häsler, Philipp Rosenstiel, Mauro D’Amato, Katja Cloppenborg-Schmidt, Sven Künzel, Matthias Laudes, Hanns-Ulrich Marschall, Wolfgang Lieb, Ute Nöthlings, Tom H Karlsen, John F Baines, Andre Franke

Nature genetics
2016

Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.

David Ellinghaus, Luke Jostins, Sarah L Spain, Adrian Cortes, Jörn Bethune, Buhm Han, Yu Rang Park, Soumya Raychaudhuri, Jennie G Pouget, Matthias Hübenthal, Trine Folseraas, Yunpeng Wang, Tonu Esko, Andres Metspalu, Harm-Jan Westra, Lude Franke, Tune H Pers, Rinse K Weersma, Valerie Collij, Mauro D’Amato, Jonas Halfvarson, Anders Boeck Jensen, Wolfgang Lieb, Franziska Degenhardt, Andreas J Forstner, Andrea Hofmann, – -, Stefan Schreiber, Ulrich Mrowietz, Brian D Juran, Konstantinos N Lazaridis, Søren Brunak, Anders M Dale, Richard C Trembath, Stephan Weidinger, Michael Weichenthal, Eva Ellinghaus, James T Elder, Jonathan N W N Barker, Ole A Andreassen, Dermot P McGovern, Tom H Karlsen, Jeffrey C Barrett, Miles Parkes, Matthew A Brown, Andre Franke

Nature genetics
2016

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