Prof. Dr. rer. nat. Andre Franke
Phone: +49 (0)431 - 500 - 15 112
Institute: Institute of Clinical Molecular Biology (IKMB) / Kiel University (CAU), University Medical Center Schleswig-Holstein (UKSH)
Address: Rosalind-Franklin-Str. 12, 24105 Kiel, Germany
Group: Genetics and Bioinformatics
Platforms: Competence Center for Genomic Analysis Kiel (CCGA)
Andre Franke is the speaker of the RU 5043 miTarget and principle investigator of project 1. He holds a W3- professorship at Kiel University and is one of three directors of the Institute of Clinical Molecular Biology. He leads the Genetics and Bioinformatics Subgroup of the institute and is responsible for the high-throughput facilities (including the data analysis and management teams) in the Centre for Molecular Biosciences (ZMB). He also serves as the speaker of the DFG Research Training Group 1743 Genes, Environment and Inflammation.
- Molecular genetics
- Next-generation sequencing
- Technology development
Host genetic factors related to innate immunity, environmental sensing and cellular functions are associated with human skin microbiota.
Distinct Longitudinal Changes in Immunoglobulin G N-Glycosylation Associate with Therapy Response in Chronic Inflammatory Diseases.
International journal of molecular sciences
DNA methyltransferase 3A controls intestinal epithelial barrier function and regeneration in the colon.
MAGScoT – a fast, lightweight, and accurate bin-refinement tool.
Short-term physical exercise impacts on the human holobiont obtained by a randomised intervention study.
Ecology impacts the decrease of Spirochaetes and Prevotella in the fecal gut microbiota of urban humans.
Sugar-Induced Obesity and Insulin Resistance Are Uncoupled from Shortened Survival in Drosophila.
Genomewide Association Study of Severe Covid-19 with Respiratory Failure.
New England journal of medicine
Elucidating the Influence of Chromosomal Architecture on Transcriptional Regulation in Prokaryotes – Observing Strong Local Effects of Nucleoid Structure on Gene Regulation.
Frontiers in Microbiology
Low-Avidity CD4+ T Cell Responses to SARS-CoV-2 in Unexposed Individuals and Humans with Severe COVID-19.
Immunity (Cambridge, Mass.)
Metabolic Functions of Gut Microbes Associate With Efficacy of Tumor Necrosis Factor Antagonists in Patients with Inflammatory Bowel Diseases.
Gastroenterology (New York, N.Y. 1943)
Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy.
Protein-coding variants contribute to the risk of atopic dermatitis and skin-specific gene expression.
Journal of allergy and clinical immunology
Faecal microbiota composition associates with abdominal pain in the general population.
Gut : journal of the British Society of Gastroenterology
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.