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Multi-centered T cell repertoire profiling identifies alterations in the immune repertoire of individuals with inflammatory bowel disease across different disease stages
Largest-to-date T-cell receptor (TCR) alpha profiling across three different cohorts with inflammatory bowel diseases, identifies robust sets of disease-associated clonotypes and proposing a potential new therapeutic and etiologic leads.
Inflammatory bowel disease (IBD) remains incurable, …read more
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Our mission
Patterns of gut microbiome dysbiosis in patients with inflammatory bowel diseases are inconsistent among published studies, probably owing to the heterogeneity of the disease and given the fact that patients enrolled in research studies are often treated and in remission. Therefore, more microbiome studies in “early” (incident) patients that are treatment-naïve and in high-risk individuals are needed. In addition, the microbiome field has to move from association to rather mechanistic studies in order to understand the actual functions and to also prove the associations that serve as hypotheses.
Institute of Clinical Molecular Biology
Kiel University
Rosalind-Franklin-Str. 12
24105 Kiel
Spokesperson
Prof. Dr. rer. nat. Andre Franke
Fon: +49 (0)431-500-15112
a.franke@ikmb-uni-kiel.de
Coordination
Dr. oec. troph. Jana Koop
Fon: +49 (0)431 500-15114
j.koop@ikmb.uni-kiel.de