Facts

Dr. rer. nat. Felix Sommer

Phone: +49(0)431-500-15146
E-Mail: f.sommer@ikmb.uni-kiel.de
Website:
www.sommerlab.net
www.ikmb.uni-kiel.de/research/junior-research-groups/functional-host-microbiome-research
www.ikmb.uni-kiel.de/people/scientists/felix-sommer
Institute: Institute of Clinical Molecular Biology (IKMB) / Kiel University (CAU), University Medical Center Schleswig-Holstein (UKSH)
Address: Rosalind-Franklin-Str. 12, 24105 Kiel, Germany
Group: Junior Research Group Functional Host-Microbiome Research and Systems Immunology

Felix Sommer is a senior scientist and principle investigator of project 5. He leads the junior research group Functional Host-Microbiome Research at the Institute of Clinical Molecular Biology (IKMB) of Kiel University and heads the “microbiome platform” for the Systems Immunology group at IKMB.

Special fields:

  • Gnotobiology
  • Host-microbiome interactions
  • Mouse models
  • Immunometabolism
  • Functional genomics

Research groups:

Project-related publications

Deletion of epithelial HKDC1 decelerates cellular proliferation and impairs mitochondrial function of tumorous epithelial cells thereby protecting from intestinal carcinogenesis.

Lea Järke, Saskia Weber-Stiehl, Kensuke Shima, Karlis Arturs Moors, Jerome Genth, Fenja Amrei Schuran, Lena Best, Markus Tschurtschenthaler, Burkhardt Flemer, Silke Lüschen, Christoph Röcken, Andreas Tholey, Christoph Kaleta, Jan Rupp, Philip Rosenstiel, Felix Sommer

PubMed (PMID: 40110992)
Cancer communications (London, England)
2025

Early intermittent hyperlipidaemia alters tissue macrophages to fuel atherosclerosis.

Minoru Takaoka, Xiaohui Zhao, Hwee Ying Lim, Costan G Magnussen, Owen Ang, Nadine Suffee, Patricia R Schrank, Wei Siong Ong, Dimitrios Tsiantoulas, Felix Sommer, Sarajo K Mohanta, James Harrison, Yaxing Meng, Ludivine Laurans, Feitong Wu, Yuning Lu, Leanne Masters, Stephen A Newland, Laura Denti, Mingyang Hong, Mouna Chajadine, Markus Juonala, Juhani S Koskinen, Mika Kähönen, Katja Pahkala, Suvi P Rovio, Juha Mykkänen, Russell Thomson, Tsuneyasu Kaisho, Andreas J R Habenicht, Marc Clement, Alain Tedgui, Hafid Ait-Oufella, Tian X Zhao, Meritxell Nus, Christiana Ruhrberg, Soraya Taleb, Jesse W Williams, Olli T Raitakari, Véronique Angeli, Ziad Mallat

PubMed (PMID: 39231480)
Nature : a weekly illustrated journal of science
2024
P5

Commensal bacteria weaken the intestinal barrier by suppressing epithelial neuropilin-1 and Hedgehog signaling.

Giulia Pontarollo, Bettina Kollar, Amrit Mann, My Phung Khuu, Klytaimnistra Kiouptsi, Franziska Bayer, Inês Brandão, Valeriya V Zinina, Jennifer Hahlbrock, Frano Malinarich, Maximilian Mimmler, Sudhanshu Bhushan, Federico Marini, Wolfram Ruf, Meriem Belheouane, John F Baines, Kristina Endres, Scott M Reba, Verena K Raker, Carsten Deppermann, Christoph Welsch, Markus Bosmann, Natalia Soshnikova, Benoit Chassaing, Mattias Bergentall, Felix Sommer, Fredrik Bäckhed, Christoph Reinhardt

PubMed (PMID: 37414930)
Nature metabolism
2023
P5

A gut bacterial signature in blood and liver tissue characterizes cirrhosis and hepatocellular carcinoma.

Maria Effenberger, Silvio Waschina, Christina Bronowski, Gregor Sturm, Oronzo Tassiello, Felix Sommer, Andreas Zollner, Christina Watschinger, Felix Grabherr, Ronald Gstir, Christoph Grander, Barbara Enrich, Reto Bale, Daniel Putzer, Angela Djanani, Alexander R Moschen, Heinz Zoller, Jan Rupp, Stefan Schreiber, Remy Burcelin, Cornelia Lass-Flörl, Zlatko Trajanoski, Georg Oberhuber, Philip Rosenstiel, Timon E Adolph, Konrad Aden, Herbert Tilg

PubMed (PMID: 37314752)
Hepatology communications
2023
P5

Endoplasmic reticulum stress in the intestinal epithelium initiates purine metabolite synthesis and promotes Th17 cell differentiation in the gut.

Jinzhi Duan, Juan D Matute, Lukas W Unger, Thomas Hanley, Alexandra Schnell, Xi Lin, Niklas Krupka, Paul Griebel, Conner Lambden, Brandon Sit, Joep Grootjans, Michal Pyzik, Felix Sommer, Sina Kaiser, Maren Falk-Paulsen, Helmut Grasberger, John Y Kao, Tobias Fuhrer, Hai Li, Donggi Paik, Yunjin Lee, Samuel Refetoff, Jonathan N Glickman, Adrienne W Paton, Lynn Bry, James C Paton, Uwe Sauer, Andrew J Macpherson, Philip Rosenstiel, Vijay K Kuchroo, Matthew K Waldor, Jun R Huh, Arthur Kaser, Richard S Blumberg

PubMed (PMID: 36917985)
Immunity (Cambridge, Mass.)
2023
P5

PUFA-induced metabolic enteritis as a fuel for Crohn’s disease.

Julian Schwärzler, Lisa Mayr, Arnau Vich Vila, Felix Grabherr, Lukas Niederreiter, Maureen Philipp, Christoph Grander, Moritz Meyer, Almina Jukic, Simone Tröger, Barbara Enrich, Nicole Przysiecki, Markus Tschurtschenthaler, Felix Sommer, Irmgard Kronberger, Jakob Koch, Richard Hilbe, Michael W Hess, Georg Oberhuber, Susanne Sprung, Qitao Ran, Robert Koch, Maria Effenberger, Nicole C Kaneider, Verena Wieser, Markus A Keller, Rinse K Weersma, Konrad Aden, Philip Rosenstiel, Richard S Blumberg, Arthur Kaser, Herbert Tilg, Timon E Adolph

PubMed (PMID: 35031299)
Gastroenterology (New York, N.Y. 1943)
2022
P5

DNA methyltransferase 3A controls intestinal epithelial barrier function and regeneration in the colon.

Antonella Fazio, Dora Bordoni, Jan W P Kuiper, Saskia Weber-Stiehl, Stephanie T Stengel, Philipp Arnold, David Ellinghaus, Go Ito, Florian Tran, Berith Messner, Anna Henning, Joana P Bernardes, Robert Häsler, Anne Luzius, Simon Imm, Finn Hinrichsen, Andre Franke, Samuel Huber, Susanna Nikolaus, Konrad Aden, Stefan Schreiber, Felix Sommer, Gioacchino Natoli, Neha Mishra, Philip Rosenstiel

PubMed (PMID: 36271073)
Nature communications
2022
P5

Short-term physical exercise impacts on the human holobiont obtained by a randomised intervention study.

Lucas Moitinho-Silva, Michelle Wegener, Sandra May, Florian Schrinner, Awais Akhtar, Teide J Boysen, Eva Schaeffer, Clint Hansen, Timo Schmidt, Malte C Rühlemann, Matthias Hübenthal, Philipp Rausch, Mustafa T Kondakci, Walter Maetzler, Stephan Weidinger, Matthias Laudes, Philip Süß, Dominik Schulte, Ralf Junker, Felix Sommer, Burkhard Weisser, Corinna Bang, Andre Franke

PubMed (PMID: 34078289)
BMC microbiology
2021
P5

Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis.

Finn Hinrichsen, Jacob Hamm, Magdalena Westermann, Lena Schröder, Kensuke Shima, Neha Mishra, Alesia Walker, Nina Sommer, Kenneth Klischies, Daniela Prasse, Johannes Zimmermann, Sina Kaiser, Dora Bordoni, Antonella Fazio, Georgios Marinos, Georg Laue, Simon Imm, Valentina Tremaroli, Marijana Basic, Robert Häsler, Ruth A Schmitz, Stefan Krautwald, Andrea Wolf, Bärbel Stecher, Philippe Schmitt-Kopplin, Christoph Kaleta, Jan Rupp, Fredrik Bäckhed, Philip Rosenstiel, Felix Sommer

PubMed (PMID: 34847376)
Cell metabolism
2021
P5

Precision Nutrition in Chronic Inflammation.

Tobias J Demetrowitsch, Kristina Schlicht, Carina Knappe, Johannes Zimmermann, Julia Jensen-Kroll, Alina Pisarevskaja, Fynn Brix, Juliane Brandes, Corinna Geisler, Georgios Marinos, Felix Sommer, Dominik M Schulte, Christoph Kaleta, Vibeke Andersen, Matthias Laudes, Karin Schwarz, Silvio Waschina

PubMed (PMID: 33329569)
Frontiers in immunology
2020

Dietary lipids fuel GPX4-restricted enteritis resembling Crohn’s disease.

Lisa Mayr, Felix Grabherr, Julian Schwärzler, Isabelle Reitmeier, Felix Sommer, Thomas Gehmacher, Lukas Niederreiter, Gui-Wei He, Barbara Ruder, Kai T R Kunz, Piotr Tymoszuk, Richard Hilbe, David Haschka, Clemens Feistritzer, Romana R Gerner, Barbara Enrich, Nicole Przysiecki, Markus Seifert, Markus A Keller, Georg Oberhuber, Susanne Sprung, Qitao Ran, Robert Koch, Maria Effenberger, Ivan Tancevski, Heinz Zoller, Alexander R Moschen, Günter Weiss, Christoph Becker, Philip Rosenstiel, Arthur Kaser, Herbert Tilg, Timon E Adolph

PubMed (PMID: 32286299)
Nature communications
2020

Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota.

Jun Wang, Louise B Thingholm, Jurgita Skiecevičienė, Philipp Rausch, Martin Kummen, Johannes R Hov, Frauke Degenhardt, Femke-Anouska Heinsen, Malte C Rühlemann, Silke Szymczak, Kristian Holm, Tönu Esko, Jun Sun, Mihaela Pricop-Jeckstadt, Samer Al-Dury, Pavol Bohov, Jörn Bethune, Felix Sommer, David Ellinghaus, Rolf K Berge, Matthias Hübenthal, Manja Koch, Karin Schwarz, Gerald Rimbach, Patricia Hübbe, Wei-Hung Pan, Raheleh Sheibani-Tezerji, Robert Häsler, Philipp Rosenstiel, Mauro D’Amato, Katja Cloppenborg-Schmidt, Sven Künzel, Matthias Laudes, Hanns-Ulrich Marschall, Wolfgang Lieb, Ute Nöthlings, Tom H Karlsen, John F Baines, Andre Franke

PubMed (PMID: 27723756)
Nature genetics
2016

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